![]() In total, 42 (17.3%) of 243 patients developed VCM nephrotoxicity. Clinical course of VCM nephrotoxicity and VCM trough concentration were assessed. The time course of renal function with VCM nephrotoxicity was compared and stratified by risk factors for VCM nephrotoxicity. We performed multivariate logistic regression analysis to assess risk factors for VCM nephrotoxicity. VCM nephrotoxicity was defined as an increase in serum creatinine levels > 50%. ![]() ![]() ![]() We conducted a retrospective analysis of patients receiving intravenous VCM treatment between June 2015 and August 2017 at Tokyo Women’s Medical University, Medical Center East. We assessed risk factors for VCM nephrotoxicity and how renal function varied over time. Although the risk factors for VCM nephrotoxicity have been evaluated, the time course of renal function during VCM treatment is unknown. Vancomycin (VCM) is used for the treatment of methicillin-resistant Staphylococcus aureus.
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